The twitcher mouse: a model for Krabbe disease and for experimental therapies.

doi:10.1111/j.1750-3639.1995.tb00601.x

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Article

The twitcher mouse: a model for Krabbe disease and for experimental therapies.

Brain pathology (Zurich, Switzerland) - 1 Jul 1995

Suzuki K, Suzuki K

Abstract excerpt

The twitcher is a naturally-occurring mouse mutant caused by an abnormality in the gene coded for galactosylceramidase. It is therefore genetically equivalent to human globoid cell leukodystrophy (Krabbe disease). Affected mice develop clinical symptoms at the onset of the active myelination peri...

Topics

Animals
Disease Models, Animal
Galactosylceramidase
Genetic Therapy
Genetic Vectors
Humans
Leukodystrophy, Globoid Cell
Mice
Mice, Neurologic Mutants
Phenotype

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