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Article

The twitcher mouse: a model for Krabbe disease and for experimental therapies.

Brain pathology (Zurich, Switzerland) - 1 Jul 1995

Suzuki K, Suzuki K

Abstract excerpt

The twitcher is a naturally-occurring mouse mutant caused by an abnormality in the gene coded for galactosylceramidase. It is therefore genetically equivalent to human globoid cell leukodystrophy (Krabbe disease). Affected mice develop clinical symptoms at the onset of the active myelination period and, if untreated, die by 35 +/- days. The pathology is very similar to that in human disease. Toxicity of...

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Identifiers

PMID: 8520724
DOI: 10.1111/j.1750-3639.1995.tb00601.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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