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Murine model of genetic demyelinating disease: The twitcher mouse

15 Oct 1995

Abstract excerpt

Twitcher mouse is an authentic murine model of human genetic demyelinating disease, globoid cell leukodystrophy (GLD), or Krabbe disease. Since its discovery at the Jackson Laboratory (Bar Harbor, ME) this model has been used extensively for the morphological, biochemical-enzymatic studies to clarify pathogenesis and also for therapeutic manipulation of genetic demyelinating disease in humans. As a result of...

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PMID: 8527855
DOI: 10.1002/jemt.1070320304

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