Article
Decrease in high density lipoprotein binding sites is associated with decrease in intracellular cholesterol efflux in dedifferentiated aortic smooth muscle cells.
Biochimica et biophysica acta - 13 May 1994
Dusserre E, Bourdillon M C, Pulcini T, Berthezene F
Abstract excerpt
One of the key features of atherosclerosis formation and progression is 'dedifferentiation' of contractile arterial smooth muscle cells (SMC) in synthetic cells. In primary cultures and subcultures before 10 and after 200 passages, SMC exhibit contractile-like, synthetic and transformed phenotype...
Topics
- Animals
- Aorta
- Arteriosclerosis
- Binding Sites
- Cell Membrane
- Cholesterol
- Intracellular Membranes
- Lipoproteins, HDL
- Lipoproteins, LDL
- Muscle, Smooth, Vascular
- Phenotype
- Rats
- Tritium