Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity.

doi:10.1099/0022-1317-74-3-351

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Article

Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity.

The Journal of general virology - 1 Mar 1993

de Wind N, Berns A, Gielkens A, Kimman T

Abstract excerpt

We have mutagenized and mapped the gene encoding the large subunit of ribonucleotide reductase (RR1) in pseudorabies virus (PRV; synonyms Aujeszky's disease virus, suid herpesvirus type 1). PRV strains carrying an oligonucleotide that leads to termination of translation of the RR1 gene are avirul...

Topics

Amino Acid Sequence
Animals
Base Sequence
Genes, Viral
Herpesvirus 1, Suid
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
Pseudorabies
Ribonucleotide Reductases
Swine
Swine Diseases
Virulence

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