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Article

Ribonucleotide reductase-deficient mutants of pseudorabies virus are avirulent for pigs and induce partial protective immunity.

The Journal of general virology - 1 Mar 1993

de Wind N, Berns A, Gielkens A, Kimman T

Abstract excerpt

We have mutagenized and mapped the gene encoding the large subunit of ribonucleotide reductase (RR1) in pseudorabies virus (PRV; synonyms Aujeszky's disease virus, suid herpesvirus type 1). PRV strains carrying an oligonucleotide that leads to termination of translation of the RR1 gene are avirulent for mice. We subsequently constructed a PRV strain carrying a deletion in the RR1 gene and also a PRV strain...

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PMID: 8383170
DOI: 10.1099/0022-1317-74-3-351

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