A defect in the inflammation-primed macrophage-activation cascade in osteopetrotic rats.

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Article

A defect in the inflammation-primed macrophage-activation cascade in osteopetrotic rats.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1994

Yamamoto N, Lindsay D D, Naraparaju V R, Ireland R A, Popoff S N

Abstract excerpt

Macrophages were activated by administration of lysophosphatidylcholine (lyso-Pc) or dodecylglycerol (DDG) to wild-type rats but not in osteopetrotic (op) mutant rats. In vitro treatment of wild-type rat peritoneal cells with lyso-Pc or DDG efficiently activated macrophages whereas treatment of o...

Topics

Animals
Cells, Cultured
Glycerides
Inflammation
Laurates
Lymphocytes
Lysophosphatidylcholines
Macrophage Activation
Macrophage Colony-Stimulating Factor
Macrophage-Activating Factors
Monoglycerides
Mutation
Osteopetrosis
Rats
beta-Galactosidase

Source

Open in PubMed

Identifiers

PMID: 8176226

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8176226-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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