Article
Alteration of the Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader by mitochondrial gene replacement and functional interaction with the translational activator protein PET111.
Molecular biology of the cell - 1 Dec 1993
Mulero J J, Fox T D
Abstract excerpt
The ability to replace wild-type mitochondrial DNA sequences in yeast with in vitro-generated mutations has been exploited to study the mechanism by which the nuclearly encoded PET111 protein specifically activates translation of the mitochondrially coded COX2 mRNA. We have generated three mutati...
Topics
- Alleles
- Base Sequence
- Chromosomes, Fungal
- DNA, Mitochondrial
- Electron Transport Complex IV
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Membrane Proteins
- Mitochondrial Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nuclear Proteins
- Peptide Initiation Factors