Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational activator PET122 by mutations in two new genes, MRP17 and PET127.

Abstract excerpt

The PET122 protein is one of three Saccharomyces cerevisiae nuclear gene products required specifically to activate translation of the mitochondrially coded COX3 mRNA. We have previously observed that mutations which remove the carboxy-terminal region of PET122 block translation of the COX3 mRNA but can be suppressed by unlinked nuclear mutations in several genes, two of which have been shown to code for proteins...

Topics

• Alleles
• Base Sequence
• Cloning, Molecular
• DNA, Fungal
• Fungal Proteins
• Gene Expression Regulation, Fungal
• Genes, Fungal
• Mitochondria
• Mitochondrial Proteins
• Molecular Sequence Data
• Mutation