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Article

In vivo analysis of Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader functions in mitochondrial translation initiation and translational activation.

Genetics - 1 Sept 1997

Dunstan H M, Green-Willms N S, Fox T D

Abstract excerpt

We have used mutational and revertant analysis to study the elements of the 54-nucleotide COX2 5'-untranslated leader involved in translation initiation in yeast mitochondria and in activation by the COX2 translational activator. Pet111p. We generated a collection of mutants with substitutions spanning the entire COX2 5'-UTL by in vitro mutagenesis followed by mitochondrial transformation and gene replacement....

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Identifiers

PMID: 9286670
DOI: 10.1093/genetics/147.1.87
PMCID: PMC1208125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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In vivo analysis of Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader functions in mitochondrial translation initiation and translational activation.PMID 9286670Read ↗

Alteration of the Saccharomyces cerevisiae COX2 mRNA 5'-untranslated leader by mitochondrial gene replacement and functional interaction with the translational activator protein PET111.Semantic proximity Read ↗

A point mutation in the 5'-untranslated leader that affects translational activation of the mitochondrial COX3 mRNA.Semantic proximity Read ↗

Reduced but accurate translation from a mutant AUA initiation codon in the mitochondrial COX2 mRNA of Saccharomyces cerevisiae.Semantic proximity Read ↗

In vivo analysis of mutated initiation codons in the mitochondrial COX2 gene of Saccharomyces cerevisiae fused to the reporter gene ARG8m reveals lack of downstream reinitiation.Semantic proximity Read ↗

Functional interactions between yeast mitochondrial ribosomes and mRNA 5' untranslated leaders.Semantic proximity Read ↗

Alteration of a novel dispensable mitochondrial ribosomal small-subunit protein, Rsm28p, allows translation of defective COX2 mRNAs.Semantic proximity Read ↗

Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-specific translational activators have orthologous functions in other budding yeasts.Semantic proximity Read ↗

Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome.Semantic proximity Read ↗

Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron.Semantic proximity Read ↗

Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational activator PET122 by mutations in two new genes, MRP17 and PET127.Semantic proximity Read ↗

Genetic analysis of RNA splicing in yeast mitochondria.Semantic proximity Read ↗

In vitro transcription/translation analysis for the identification of translation-terminating mutations.Semantic proximity Read ↗

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