Genetic instability of vaccinia virus containing artificially duplicated genome regions.

doi:10.1016/0168-1702(94)90075-2

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Article

Genetic instability of vaccinia virus containing artificially duplicated genome regions.

Virus research - 1 Jan 1994

Kriajevska M V, Zakharova L G, Altstein A D

Abstract excerpt

A double recombinant of vaccinia virus (W-lacZ/J-tk/F) was obtained, which contains two inverted copies of the virus tk gene, separated by 45 kb: (i) the native copy located in the HindIII J fragment of the virus genome was inactivated due to insertion of E. coli lacZ gene; (ii) the second active...

Topics

Animals
Blotting, Southern
Cell Line
Chlorocebus aethiops
Chromosome Mapping
Cloning, Molecular
DNA, Recombinant
DNA, Viral
Genetic Variation
Lac Operon
Models, Genetic
Phenotype
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Thymidine Kinase
Vaccinia virus
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 8165864
DOI: 10.1016/0168-1702(94)90075-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8165864-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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