Article
Fidelity of homologous recombination in vaccinia virus DNA.
Virology - 1 Jun 1995
Ball L A
Abstract excerpt
The fidelity of homologous recombination in vaccinia virus (VV) DNA was examined by constructing a viral recombinant whose genome contained a copy of the Escherichia coli lac z gene in which the central third of the gene was repeated on either side of the VV thymidine kinase (tk) gene. In this virus, homologous DNA recombination and consequent excision of the tk gene were necessary to restore the open reading...
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