Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.

doi:10.1002/jcp.1041590217

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Article

Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.

Journal of cellular physiology - 1 May 1994

Ballock R T, Heydemann A, Wakefield L M, Flanders K C, Roberts A B, Sporn M B

Abstract excerpt

Retinoic acid has been identified as a key morphogen governing pattern formation in the developing cartilaginous skeleton. Retinoids have also been implicated in the premature closure of the cartilage growth plate following vitamin A intoxication or administration of retinoids for dermatologic co...

Topics

Animals
Bone Matrix
Cartilage, Articular
Cells, Cultured
Gene Expression
Gene Expression Regulation
Isomerism
Metalloendopeptidases
Phenotype
Proteins
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
RNA, Messenger
Rats
Rats, Sprague-Dawley
Transforming Growth Factor beta
Tretinoin

Source

Open in PubMed

Identifiers

PMID: 8163572
DOI: 10.1002/jcp.1041590217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8163572-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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