Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types.

doi:10.1016/0925-4773(93)90015-p

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Article

Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types.

Mechanisms of development - 1 Nov 1993

Maltsev V A, Rohwedel J, Hescheler J, Wobus A M

Abstract excerpt

Pluripotent embryonic stem cells (ESC, ES cells) of line D3 were differentiated in vitro and via embryo-like aggregates (embryoid bodies) of defined cell number into spontaneously beating cardiomyocytes. By using RT-PCR technique, alpha- and beta-cardiac myosin heavy chain (MHC) genes were found...

Topics

Action Potentials
Animals
Cell Differentiation
Cells, Cultured
Gene Expression Regulation
Heart
Heart Atria
Heart Ventricles
Mice
Myocardium
Phenotype
Sinoatrial Node
Stem Cells

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