Article
Stem cell-derived cardiomyocytes demonstrate arrhythmic potential.
Circulation - 3 Sept 2002
Zhang Ying Ming, Hartzell Criss, Narlow Michael, Dudley Samuel C
Abstract excerpt
BACKGROUND: Cardiomyocytes (CMs) derived from pluripotent embryonic stem cells (ESCs) and embryonal carcinoma cells (ECCs) have some but not all characteristics of adult myocytes. ESCs have shown the ability to engraft in areas of myocardial damage, which suggests their use in cell transplantation therapy for cardiomyopathy. We studied the arrhythmogenic properties of CMs differentiated from mouse ESCs and ECCs....
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