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Article

Resistance to Antibiotics Mediated by Target Alterations

15 Apr 1994

Abstract excerpt

The development of resistance to antibiotics by reductions in the affinities of their enzymatic targets occurs most rapidly for antibiotics that inactivate a single target and that are not analogs of substrate. In these cases of resistance (for example, resistance to rifampicin), numerous single amino acid substitutions may provide large decreases in the affinity of the target for the antibiotic, leading to...

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PMID: 8153626
DOI: 10.1126/science.8153626

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