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Article

[Acquisition of antibiotic-resistance in bacteria by alteration of molecular target, or by the decreased permeability].

Nihon rinsho. Japanese journal of clinical medicine - 1 May 1997

Hashimoto H

Abstract excerpt

The target of an antibiotic is any essential enzyme for bacterial growth and quantitative or qualitative alteration of the enzyme or its substrate may cause resistance to the drug. Thus, the alteration of DNA gyrase and/or topoisomerase IV may result in resistance to fluoloquinolones, and alteration of beta-subunit of RNA polymerase may cause rifampicin-resistance. The cell wall synthesizing enzymes which...

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Identifiers

PMID: 9155170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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