Article

Partial deficiency of Thyroid transcription factor 1 produces predominantly neurological defects in humans and mice

2002-02-15

Abstract excerpt

Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results. In particular, no TTF1 gene defects were found in 76 individuals with thyroid dysgenesis even though a deletion of this gene in the mouse results in thyroid and lung agenesis and defective diencephal...

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Literature Corpus work: 9bfbf8fc-6b02-5e2e-ada1-81a14e5753a4
DOI: 10.1172/jci0214192

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