Article
Overexpression of C-terminally but not N-terminally truncated Myb induces fibrosarcomas: a novel nonhematopoietic target cell for the myb oncogene.
Molecular and cellular biology - 1 Apr 1994
Press R D, Reddy E P, Ewert D L
Abstract excerpt
The myb oncogene encodes a DNA-binding transcriptional transactivator which can become a hematopoietic cell-transforming protein following the deletion of amino acid sequences from either its amino or carboxyl terminus. Although a number of hematopoietic tumors express terminally deleted variants...
Topics
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chick Embryo
- Chickens
- DNA Primers
- DNA-Binding Proteins
- Fibrosarcoma
- Gene Expression
- Genetic Variation
- Genetic Vectors
- Molecular Sequence Data
- Oncogenes
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myb
- Proto-Oncogenes