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Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells

15 Jul 2011

Abstract excerpt

BACKGROUND: Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian tiger mosquitoes. To study the processing of envelope proteins E1 and E2 and to develop a CHIKV subunit vaccine, C-terminally his-tagged E1 and E2 envelope...

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PMID: 21762510
DOI: 10.1186/1743-422x-8-353

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