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Article

Mutational analysis of MLH1 and MSH2 in 25 prospectively-acquired RER+ endometrial cancers.

Genes, chromosomes & cancer - 1 Mar 1997

Kowalski L D, Mutch D G, Herzog T J, Rader J S, Goodfellow P J

Abstract excerpt

Mutations in the DNA mismatch repair (MMR) genes MLH1 and MSH2 have been linked to several human cancers which display the replication error (RER) phenotype. Germline mutations in these two genes have been implicated in about 90% of families with hereditary nonpolyposis colorectal cancer (HNPCC). A significant proportion of endometrial cancers, the second most common malignancy of the HNPCC syndrome, also exhibit...

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Source

Identifiers

PMID: 9071575
DOI: 10.1002/(sici)1098-2264(199703)18:3<219::aid-gcc8>3.0.co;2-4

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutational analysis of MLH1 and MSH2 in 25 prospectively-acquired RER+ endometrial cancers.PMID 9071575Read ↗

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Identification of germline MSH2 gene mutations in endometrial cancer not fulfilling the new clinical criteria for hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

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