Article
[Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes].
Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence - 1 Feb 1994
Iwahashi K, Nakamura K, Suwaki H, Miyatake R, Matsuo Y, Ichikawa Y, Orino K
Abstract excerpt
The genotypes of the CYP2E1 and ALDH2 loci in alcoholic and non-alcoholic (healthy) Japanese were investigated to examine the relationship between the polymorphisms of CYP2E1 (C1/C2) and ALDH2 (ALDH2*1/ALDH2*2), and the susceptibility to alcoholism. There was no significant difference in C2 gene frequency between alcoholics (0.20) and non-alcoholics (0.19), while there was a significant difference in ALDH2 allele...
Topics
- Alcoholism
- Aldehyde Dehydrogenase
- Aldehydes
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Genotype
- Humans
- Male
- Oxidoreductases, N-Demethylating
- Polymorphism, Genetic