Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men.

doi:10.1007/s004399900133

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Article

Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men.

Human genetics - 1 Oct 1999

Sun F, Tsuritani I, Honda R, Ma Z Y, Yamada Y

Abstract excerpt

To evaluate the independent and interactive contributions of alcohol dehydrogenase-2 (ADH2), aldehyde dehydrogenase-2 (ALDH2) and ethanol-induced isozyme cytochrome P450-2E1 (CYP2E1) genes to alcohol consumption large enough to induce health problems, 643 healthy Japanese men aged between 23 and 64 years, recruited from two different occupational groups, were analyzed for genotype and drinking habits. The...

Topics

Adult
Alcohol Dehydrogenase
Alcohol Drinking
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Alleles
Cytochrome P-450 CYP2E1
Ethanol
Genotype
Heterozygote
Homozygote
Humans
Japan
Male
Middle Aged
Polymorphism, Genetic
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 10543395
DOI: 10.1007/s004399900133

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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