Article
Molecular analysis of juvenile Huntington disease: the major influence on (CAG)n repeat length is the sex of the affected parent.
Human molecular genetics - 1 Oct 1993
Telenius H, Kremer H P, Theilmann J, Andrew S E, Almqvist E, Anvret M, Greenberg C, Greenberg J, Lucotte G, Squitieri F
Abstract excerpt
Juvenile Huntington disease (HD), characterised by onset of symptoms before the age of 20 with rigidity and intellectual decline, is associated with a predominance of affected fathers. In order to investigate the molecular basis for the observed parental effect, we have analysed the CAG trinucleo...
Topics
- Adolescent
- Adult
- Age of Onset
- Alleles
- Base Sequence
- Child
- Chromosomes, Human, Pair 4
- Cohort Studies
- Fathers
- Female
- Genes
- Humans
- Huntington Disease
- Incidence
- Male
- Molecular Sequence Data