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Article

Correspondence of increased debrisoquine 4-monooxygenase activity with seizure-susceptibility in Mongolian gerbils.

Journal of the neurological sciences - 1 Jan 1994

Iwahashi K, Suwaki H, Matsuo Y, Ichikawa Y, Hosokawa K

Abstract excerpt

Four drug-metabolizing activities in Wistar rat and Mongolian gerbil liver microsomes were investigated to clarify the biochemical basis of convulsions. No significant associations were observed between the susceptibility to the tonic-clonic seizures in Mongolian gerbils and the drug-metabolizing...

Topics

Animals
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Electroencephalography
Female
Genetic Predisposition to Disease
Gerbillinae
Male
Mixed Function Oxygenases
Rats
Rats, Wistar
Seizures

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8133306
DOI: 10.1016/0022-510x(94)90150-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8133306-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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