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Article

Klebsiella oxytoca: resistance to aztreonam by overproduction of the chromosomally encoded beta-lactamase.

FEMS microbiology letters - 1 Feb 1994

Fournier B, Arlet G, Lagrange P H, Philippon A

Abstract excerpt

Aztreonam-resistant Klebsiella oxytoca strain SL7811 was selected on agar containing 1 microgram of aztreonam per ml from a susceptible strain SL781. The MICs for the resistant mutant towards penicillins, aztreonam and ceftriaxone were much higher, to cefotaxime slightly higher and to ceftazidime unchanged. Synthesis of beta-lactamase was 223-fold greater in the mutant compared with the susceptible strain. SL781...

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Identifiers

PMID: 8132152
DOI: 10.1111/j.1574-6968.1994.tb06671.x

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