Article
Klebsiella oxytoca: resistance to aztreonam by overproduction of the chromosomally encoded beta-lactamase.
FEMS microbiology letters - 1 Feb 1994
Fournier B, Arlet G, Lagrange P H, Philippon A
Abstract excerpt
Aztreonam-resistant Klebsiella oxytoca strain SL7811 was selected on agar containing 1 microgram of aztreonam per ml from a susceptible strain SL781. The MICs for the resistant mutant towards penicillins, aztreonam and ceftriaxone were much higher, to cefotaxime slightly higher and to ceftazidime unchanged. Synthesis of beta-lactamase was 223-fold greater in the mutant compared with the susceptible strain. SL781...
Topics
- Amino Acid Sequence
- Aztreonam
- Base Sequence
- Cefotaxime
- Chromosomes, Bacterial
- Cloning, Molecular
- DNA, Bacterial
- Drug Resistance, Microbial
- Escherichia coli
- Klebsiella
- Molecular Sequence Data