Mechanisms of resistance to ceftazidime/avibactam in mutants derived in vitro from Klebsiella pneumoniae producing OXA-48-like enzymes.

doi:10.1093/jac/dkaf360

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Article

Mechanisms of resistance to ceftazidime/avibactam in mutants derived in vitro from Klebsiella pneumoniae producing OXA-48-like enzymes.

The Journal of antimicrobial chemotherapy - 2 Dec 2025

Blanco-Martín T, Guzmán-Puche J, Hernández-García M, Muñoz-Rosa M, Elías-López C, Riazzo C, Torre-Cisneros J, Arca-Suárez J, Causse M, Bou G, Cantón R, Martínez-Martínez L

Abstract excerpt

OBJECTIVES: To generate in vitro ceftazidime-avibactam-resistant mutants derived from Klebsiella pneumoniae producing OXA-48 or OXA-48 derivatives OXA-131 and OXA-232 carbapenemases, to define their antimicrobial susceptibility phenotype and to analyse mutations potentially involved in resistance to ceftazidime-avibactam. METHODS: Mutants were obtained by plating overnight bacterial cultures on Mueller-Hinton...

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Topics

Ceftazidime
Klebsiella pneumoniae
Azabicyclo Compounds
beta-Lactamases
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Combinations

Anti-Bacterial Agents

Whole Genome Sequencing

Mutation

Humans

Bacterial Proteins

Klebsiella Infections

Drug Resistance, Multiple, Bacterial

Drug Resistance, Bacterial

Source

Open in PubMed

Identifiers

PMID: 41016856
DOI: 10.1093/jac/dkaf360

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