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Article

Studies on lymphocyte characteristics in patients with homozygous alpha 1-proteinase inhibitor deficiency during substitution therapy.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace - 1 Dec 1993

Schoenfeld N, Schmitt M, Remy N, Wahn U, Loddenkemper R

Abstract excerpt

Alpha 1-proteinase inhibitor (alpha 1-PI) has been demonstrated to suppress mitogen-induced lymphocyte response in vitro. To evaluate the effect of intravenous application of human alpha 1-PI (Prolastin HS) on cellular immunity, we determined total lymphocyte count, lymphocyte subsets and lymphocyte response to concanavalin A, before and 24 h after infusion of 60 mg.kg-1 body weight alpha 1-PI in eight patients...

Topics

Homozygote
Humans
Lymphocyte Activation
Lymphocyte Subsets
Phenotype
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8124298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8124298-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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