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Article

Clinical pharmacokinetics of alpha 1-antitrypsin in homozygous PiZ deficient patients.

Clinical pharmacokinetics - 1 Aug 1992

Constans J, Carles P, Boneu A, Arnaud J, Tufenkji A E, Pujazon M C, Tavera C

Abstract excerpt

A pharmacokinetic study of alpha 1-antitrypsin (ATT) was performed in 2 groups of homozygous PiZ-deficient patients (treated and untreated) and 1 group of healthy volunteers. The distribution of the 131I-labelled protein corresponds to a 3-compartment model. The intravenously administered protein diffused quickly to the extravascular compartment where some retention occurred. No significant difference in AAT...

Topics

Adult
Aged
Analysis of Variance
Female
Half-Life
Homozygote
Humans
Injections, Intravenous
Male
Metabolic Clearance Rate
Middle Aged
Phenotype

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alpha 1-Antitrypsin

alpha 1-Antitrypsin Deficiency

Source

Identifiers

PMID: 1511530
DOI: 10.2165/00003088-199223020-00007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1511530-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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