Article
Alzheimer's disease: molecular genetics and transgenic animal models.
Behavioural brain research - 30 Nov 1993
Lannfelt L, Folkesson R, Mohammed A H, Winblad B, Hellgren D, Duff K, Hardy J
Abstract excerpt
Disease-causing mutations in the amyloid precursor protein (APP) gene have been found on chromosome 21 during the last 2 years in some early onset Alzheimer's disease (AD) families. Genetic evidence shows that other genes than the APP are also involved in the aetiology of AD. Linkage to a loci on chromosome 14 has been found in early onset disease. The identification of APP mutation has led to the realization...
Topics
- Aged
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Chromosomes, Human, Pair 21
- Disease Models, Animal
- Humans
- Mice
- Mice, Transgenic