Article
Rapid molecular characterization of Hb H disease in Chinese by polymerase chain reaction.
Annals of hematology - 1 Jan 1994
Chang J G, Liu T C, Perng L I, Chiou S S, Chen T P, Chen P H, Lin C P
Abstract excerpt
We have developed a rapid method to molecularly distinguish different types of Hb H disease. The study depended on (a) most of the Hb H disease in Taiwan having an alpha-thalassemia-1 of the Southeast Asia type (--SEA) in one allele and (b) the differences of X box of alpha-globin gene cluster in the other allele. To detect the --SEA allele, we utilized the primers located on either side of the breakpoint to do...
Topics
- Alleles
- Base Sequence
- China
- Gene Deletion
- Globins
- Hemoglobins
- Hemoglobins, Abnormal
- Humans
- Molecular Probes
- Molecular Sequence Data
- Multigene Family
- Polymerase Chain Reaction