Article
Molecular characterization of Hb H disease by polymerase chain reaction.
Acta haematologica - 1 Jan 1993
Chen T P, Lin S F, Chang J G, Tsao C J, Liu T C, Chiou S S, Liu H W
Abstract excerpt
We utilized the PCR method to amplify the alpha-thalassemia-1 breakpoint area of the Southeast Asia type and several regions of the alpha-globin gene cluster to diagnose rightward deletion (-alpha 3.7), leftward deletion (-alpha 4.2) or nondeletion forms of the Hb H disease. For the nondeletion form, a natural restriction site of MseI was used to detect the Hb Constant Spring (Hb CS) or other termination codon...
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