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Article

Detection of three common, deletional alpha-thalassemia determinants in Southern China by a single-tube multiplex polymerase chain reaction method.

Hemoglobin - 1 Feb 2004

Liu Jing Zhong, Ou Cai Ying, Wang Li Rong, Xiao Bai, Huang Li Jia, Chen Li Chang

Abstract excerpt

alpha-Thalassemia (thal) is one of the most common inherited disorders in the world and in Southern China. Three large deletions of the alpha-globin gene, namely the -alpha3.7 and -alpha4.2 (single gene deletions), and --SEA (Southeast Asian double gene deletion), are the main alpha-thal abnormalities in Southern China. We have developed a reliable, single-tube multiplex polymerase chain reaction (m-PCR) assay...

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PMID: 15008263
DOI: 10.1081/hem-120028885

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SEA

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