Article
Switch recombination in normal IgA1+ B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Irsch J, Irlenbusch S, Radl J, Burrows P D, Cooper M D, Radbruch A H
Abstract excerpt
Most B lymphocytes in normal individuals express two classes of cell-surface immunoglobulins, IgM and IgD. The specificity of the two antigen receptors is identical since they are produced by transcription and differential splicing of the same variable region gene segment to the heavy-chain const...
Topics
- Antigens, CD
- B-Lymphocyte Subsets
- Blood Cells
- Cell Cycle
- Cell Separation
- Flow Cytometry
- Genotype
- Humans
- Immunoglobulin A
- Immunoglobulin Class Switching
- Immunoglobulin Constant Regions
- Immunoglobulin Heavy Chains
- Immunoglobulin Isotypes
- Immunophenotyping
- Receptors, Antigen, B-Cell
- Recombination, Genetic