Article
Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians.
Nature communications - 1 Jan 2013
Cheng Gang, Gao Yang, Wang Tao, Sun Yi, Wei Zhiguo, Li Lingxiao, Ren Liming, Guo Ying, Hu Xiaoxiang, Lu Yan, Wang Xumin, Liu Guiming, Zhang Chenglin, Yu Jun, Pan-Hammarström Qiang, Hammarström Lennart, Wu Xiaobing, Li Ning, Zhao Yaofeng
Abstract excerpt
Crocodilians are a group of reptiles that are closely related to birds and are thought to possess a strong immune system. Here we report that the IgH locus in the Siamese crocodile and the Chinese alligator contains multiple μ genes, in contrast to other tetrapods. Both the μ2 and μ3 genes are expressed through class-switch recombination involving the switch region and germline transcription. Both IgM1 and IgM2...
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