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Article

Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity.

Journal of virology - 1 Mar 1994

Ma X Y, Sova P, Chao W, Volsky D J

Abstract excerpt

The infectivity factor of human immunodeficiency virus type 1 (HIV-1), Vif, contains two cysteine residues which are highly conserved among animal lentiviruses. We introduced substitutions of leucine for cysteine residues in the vif gene of a full-length HIV-1 clone to analyze their roles in viral infection. Mutant viruses containing substitutions in either Cys-114, Cys-133, or both displayed a vif-negative...

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Identifiers

PMID: 8107232
DOI: 10.1128/JVI.68.3.1714-1720.1994
PMCID: PMC236631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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