Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity.

doi:10.1128/JVI.68.3.1714-1720.1994

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Article

Cysteine residues in the Vif protein of human immunodeficiency virus type 1 are essential for viral infectivity.

Journal of virology - 1 Mar 1994

Ma X Y, Sova P, Chao W, Volsky D J

Abstract excerpt

The infectivity factor of human immunodeficiency virus type 1 (HIV-1), Vif, contains two cysteine residues which are highly conserved among animal lentiviruses. We introduced substitutions of leucine for cysteine residues in the vif gene of a full-length HIV-1 clone to analyze their roles in vira...

Topics

Amino Acid Sequence
Base Sequence
Cysteine
Gene Products, vif
Genetic Complementation Test
HIV Core Protein p24
HIV Envelope Protein gp41
HIV-1
Humans
Molecular Sequence Data
Mutation
Protein Processing, Post-Translational
Sequence Homology, Nucleic Acid
Structure-Activity Relationship
T-Lymphocytes
Tumor Cells, Cultured
Viral Proteins
Virulence

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Identifiers

PMID: 8107232
DOI: 10.1128/JVI.68.3.1714-1720.1994
PMCID: PMC236631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8107232-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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