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Article

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells.

Journal of virology - 1 Aug 1993

von Schwedler U, Song J, Aiken C, Trono D

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) vif gene encodes a 23-kDa protein of unknown function, also produced by most other known lentiviruses. Vif was found to be essential for the spread of HIV-1 in peripheral blood lymphocytes and in primary macrophages, as well as in some but not all established T-cell lines. Vif was required at the stage of viral particle formation, for cell-to-cell as well as for...

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Identifiers

PMID: 8331734
DOI: 10.1128/JVI.67.8.4945-4955.1993
PMCID: PMC237882

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