Evidence of combined effect of amino acid substitutions within G‐H and B‐C loops of VP1 conferring serological heterogeneity in foot‐and‐mouth disease virus serotype A

Abstract excerpt

Foot-and-mouth disease virus (FMDV) serotype A exhibits a higher degree of genetic and antigenic diversity resulting in frequent vaccine failure due to serological mismatch between the vaccine and heterologous strains. Currently, knowledge on the molecular basis of antigenic relationships among the FMDVs is limited; nevertheless, intratype antigenic variation due to mutation(s) is widely considered as the main...

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