Transfer RNA mutation and the malleability of the genetic code.

doi:10.1006/jmbi.1994.1094

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Article

Transfer RNA mutation and the malleability of the genetic code.

Journal of molecular biology - 4 Feb 1994

Schultz D W, Yarus M

Abstract excerpt

We propose that evolutionary reassignment of codons is facilitated by a translationally ambiguous intermediate. For example, recently discovered tRNA mutations that allow relatively efficient simultaneous cognate and near-cognate coding (sharing 2 contiguous nt) in vivo may speed reassignment of...

Topics

Biological Evolution
Codon
Escherichia coli
Genetic Code
Models, Genetic
Mutation
Nucleic Acid Conformation
Protein Biosynthesis
RNA, Transfer

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