Article
A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain.
Experimental cell research - 25 Feb 1996
Hirai R, Fijita T
Abstract excerpt
In the signal transduction of transforming growth factor-beta (TGF-beta), the TGF-beta type II receptor (betaR-II) binds TGF-beta, presents the ligand to type I receptor, and forms a heterodimeric receptor complex that functions as an active signaling receptor. We isolated cDNA clones encoding an...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Division
- Cells, Cultured
- Cloning, Molecular
- DNA, Complementary
- Endothelium, Vascular
- Genetic Variation
- Humans
- Mice
- Molecular Sequence Data
- Plasminogen Activator Inhibitor 1
- Promoter Regions, Genetic
- Protein Serine-Threonine Kinases
- RNA, Messenger
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta