Article
Differential mRNA stabilities affect mRNA levels in mutant mouse myeloma cells.
Somatic cell and molecular genetics - 1 Jan 1991
Genovese C, Harrold S, Milcarek C
Abstract excerpt
A series of mouse myeloma cell lines producing mutant gamma 2b immunoglobin heavy chains, which resemble heavy chain disease proteins, were analyzed for messenger RNA abundance as a function of mRNA alterations. A mutation effectively deleting the gamma 2b-CH1 domain of the mRNA had little or no...
Topics
- Animals
- Blotting, Northern
- Gene Expression
- Genes, Immunoglobulin
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Isotypes
- Immunoglobulin gamma-Chains
- Immunoglobulin kappa-Chains
- In Vitro Techniques
- Mice
- Mutation
- Plasmacytoma
- RNA, Messenger
- Transcription, Genetic
- Tumor Cells, Cultured