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Article

Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes.

Acta oncologica (Stockholm, Sweden) - 1 Jan 2004

Olsen Karen E, Knudsen Helle, Rasmussen Birgitte B, Balslev Eva, Knoop Ann, Ejlertsen Bent, Nielsen Kirsten V, Schönau Andreas, Overgaard Jens

Abstract excerpt

New strategies for improving treatment of patients with breast carcinoma have focused on the HER2 oncoprotein with regard to response to traditional therapy regimes and the effect of a new drug specifically directed against the protein. Furthermore, the status of the topoisomerase IIalpha (TOP2A) gene has been suggested as a predictive marker of anthracycline treatment. In this study of 120 tumours,...

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Share to DNA Topoisomerases, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 15068318
DOI: 10.1080/02841860310019007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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