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Article

Nucleotide pool-sensitive selection of the transcriptional start site in vivo at the Salmonella typhimurium pyrC and pyrD promoters.

Journal of bacteriology - 1 Jul 1993

Sørensen K I, Baker K E, Kelln R A, Neuhard J

Abstract excerpt

Expression of the Salmonella typhimurium pyrC and pyrD genes is regulated in response to fluctuations in the intracellular CTP/GTP pool ratio. The repressive mechanism involves the formation of a stable secondary structure (hairpin) at the 5' ends of the transcripts that precludes translational initiation by sequestering sequences required for ribosomal binding. The potential for hairpin formation is controlled...

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Identifiers

PMID: 8100568
DOI: 10.1128/jb.175.13.4137-4144.1993
PMCID: PMC204843

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Source receipt: pubmed, retrieved 7 Sept 2026.

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