Article
CTP limitation increases expression of CTP synthase in Lactococcus lactis.
Journal of bacteriology - 1 Nov 2003
Jørgensen Casper Møller, Hammer Karin, Martinussen Jan
Abstract excerpt
CTP synthase is encoded by the pyrG gene and catalyzes the conversion of UTP to CTP. A Lactococcus lactis pyrG mutant with a cytidine requirement was constructed, in which beta-galactosidase activity in a pyrG-lacLM transcriptional fusion was used to monitor gene expression of pyrG. A 10-fold decrease in the CTP pool induced by cytidine limitation was found to immediately increase expression of the L. lactis pyrG...
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