Article
A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles.
The Journal of clinical investigation - 1 Jun 1993
Sasso E H, Willems van Dijk K, Bull A P, Milner E C
Abstract excerpt
The immunoglobulin VH gene 51p1, a member of the large VH1 gene family, is preferentially expressed by B cells in the fetus and in chronic lymphocytic leukemia (CLL) and appears to be the source for many cryoglobulin rheumatoid factors. Polymorphism of 51p1 may therefore be functionally important...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Fetus
- Genes, Immunoglobulin
- Genome, Human
- Humans
- Leukocytes
- Molecular Sequence Data
- Multigene Family
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Polymorphism, Restriction Fragment Length
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid