Somatic cell mapping of the bovine prion protein gene and restriction fragment length polymorphism studies in cattle and sheep.

doi:10.1111/j.1365-2052.1993.tb00914.x

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Article

Somatic cell mapping of the bovine prion protein gene and restriction fragment length polymorphism studies in cattle and sheep.

Animal genetics - 1 Feb 1993

Ryan A M, Womack J E

Abstract excerpt

Brains affected by the progressive neurological disease bovine spongiform encephalopathy (BSE) contain scrapie-associated fibrils and the protease-resistant isoform of prion protein. The gene encoding the normal host prion protein (PRNP) has been mapped to human chromosome 20 and mouse chromosome...

Topics

Alleles
Animals
Blotting, Southern
Cattle
Chromosome Mapping
DNA Restriction Enzymes
Gene Frequency
Nerve Tissue Proteins
Pedigree
Polymorphism, Restriction Fragment Length
PrPSc Proteins
Prions
Restriction Mapping
Sheep

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