Article
Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with Down's syndrome.
Neurobiology of aging - 1 Jan 2000
Grossmann A, Kukull W A, Jinneman J C, Bird T D, Villacres E C, Larson E B, Rabinovitch P S
Abstract excerpt
Abnormalities in intracellular free calcium ([Ca2+]i) regulation are likely to play a role in brain aging and have been described in cells from patients with Alzheimer's disease (AD). [Ca2+]i acts as a second messenger in transmembrane signaling and regulates diverse functions in many cell types....
Topics
- Adult
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Antibodies, Monoclonal
- CD3 Complex
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Calcium
- Down Syndrome
- Female
- Flow Cytometry
- Fluorescent Dyes
- Humans
- Indoles
- Male
- Middle Aged