Article
Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with Down's syndrome.
Neurobiology of aging - 1 Jan 2000
Grossmann A, Kukull W A, Jinneman J C, Bird T D, Villacres E C, Larson E B, Rabinovitch P S
Abstract excerpt
Abnormalities in intracellular free calcium ([Ca2+]i) regulation are likely to play a role in brain aging and have been described in cells from patients with Alzheimer's disease (AD). [Ca2+]i acts as a second messenger in transmembrane signaling and regulates diverse functions in many cell types. Therefore, abnormalities in [Ca2+]i response may have far-ranging effects. Using flow cytometric assay for [Ca2+]i, we...
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