Article
Genetic analysis of murine senile amyloidosis.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 1993
Naiki H, Higuchi K, Shimada A, Takeda T, Nakakuki K
Abstract excerpt
BACKGROUND: Recent studies have suggested that not only the genotypes of apolipoprotein A-II, the precursor protein of murine senile amyloid fibrils, but also other genetic factors may contribute to the pathogenesis of murine senile amyloidosis. EXPERIMENTAL DESIGN: We investigated the mode of in...
Topics
- Aging
- Amyloidosis
- Animals
- DNA
- Dementia
- Genotype
- Glutamine
- Mice
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Proline
- Protein Precursors
- Serum Amyloid A Protein
- Spectrometry, Fluorescence