Article
Linkage of protection against amyloid fibril formation in the mouse to a single, autosomal dominant gene.
The Journal of experimental medicine - 1 Jun 1995
Gonnerman W A, Elliott-Bryant R, Carreras I, Sipe J D, Cathcart E S
Abstract excerpt
Inbred strains of mice provide a model for studies of the pathogenesis of amyloid A (AA) amyloidosis. All susceptible strains of mice described to date codominantly express two serum amyloid A (apoSAA) isoforms, apoSAA1 and apoSAA2, of which only apoSAA2 serves as a precursor for amyloid fibrils....
Topics
- Amino Acid Sequence
- Amyloidosis
- Animals
- Crosses, Genetic
- Female
- Gene Expression
- Genes, Dominant
- Genetic Linkage
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred CBA
- Mice, Inbred Strains
- Molecular Sequence Data
- Serum Amyloid A Protein
- Species Specificity