Article
Amyloid resistance in A/J mice is not determined by genetic variants at, or close to, the serum amyloid P component locus.
Clinical and experimental immunology - 1 Apr 1991
Whitehead A S, Gonnerman W, Steel D M, Zahedi K
Abstract excerpt
An experimental model to assess the utility of variants of the serum amyloid P component (SAP) gene in predicting resistance to amyloidosis resulting from chronic inflammation was developed. F2 mice were generated from amyloid resistant (A/J) and amyloid susceptible (C57BL/6J) progenitor strains. Mice were injected daily with azocasein for 30 days, a treatment protocol determined to produce little amyloid...
Topics
- Amyloidosis
- Animals
- Blotting, Southern
- Caseins
- DNA
- Disease Models, Animal
- Female
- Genotype
- Male
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL