Article
Genetic characterization of the role of the two HOX proteins, Proboscipedia and Sex Combs Reduced, in determination of adult antennal, tarsal, maxillary palp and proboscis identities in Drosophila melanogaster.
Development (Cambridge, England) - 1 Dec 1997
Percival-Smith A, Weber J, Gilfoyle E, Wilson P
Abstract excerpt
Both Proboscipedia (PB) and Sex Combs Reduced (SCR) activities are required for determination of proboscis identity. Here we show that simultaneous removal of PB and SCR activity results in a proboscis-to-antenna transformation. Dominant negative PB molecules inhibit the activity of SCR indicating that PB and SCR interact in a multimeric protein complex in determination of proboscis identity. These data suggest...
Topics
- Animals
- Body Patterning
- DNA, Recombinant
- Drosophila Proteins
- Drosophila melanogaster
- Extremities
- Gene Expression Regulation, Developmental
- Head
- Homeodomain Proteins
- Insect Proteins