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Malaria and Dengue Mosquito Vectors from Lao PDR Show a Lack of the rdl Mutant Allele Responsible for Cyclodiene Insecticide Resistance.

Journal of medical entomology - 4 May 2020

Marcombe Sebastien, Thammavong Phoutmany, Luangamath Phonesavanh, Chonephetsarath Somsanith, Phommavanh Nothasin, Lakeomany Khaitong, Nilaxay Somphat, Rahmani Zuhal, Saverton Penelope J, Abdullateef Omobolanle H, Forward Jordan, Jacob Anna E, Khadam Safina, Ali Wlaa, Boer Chloé, Kakinuma Hayato, Hawkins Joseph, Longstreeth Rosie, Portwood Natalie M, Smee Madeleine, Brown Natasha, Kuyucu Nursu C, Lechmere Susannah, Stieger Gabriela, Maithaviphet Santi, Nambanya Simone, Brey Paul T, Jones Andrew K

Abstract excerpt

The gamma-aminobutyric acid (GABA) receptor, RDL, plays important roles in neuronal signaling and is the target of highly effective insecticides. A mutation in RDL, commonly A296S, underlies resistance to several insecticides such as cyclodienes. Even though the use of cyclodienes has been banned, the occurrence of mutations substituting A296 is notably high in mosquitoes from several countries. Here, we report a...

Topics

Aedes
Alleles
Animals
Anopheles
Dengue
Dieldrin
Insect Proteins
Insecticide Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insecticides

Laos

Malaria

Mosquito Vectors

Mutation

Source

Identifiers

PMID: 31807752
DOI: 10.1093/jme/tjz227

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